Drugs and Pregnancy

Sometimes drugs are essential for the health of the pregnant woman and the foetus. In such cases, before taking any drug (including over-the-counter drugs) or dietary supplement (including medicinal herbs), a pregnant woman should consult her doctor. And doctor recommends to take certain vitamins and minerals during pregnancy.

Effect of drugs on foetus

Drugs taken by a pregnant woman reach the foetus primarily by crossing the placenta, the same route taken by oxygen and nutrients, which are needed for the foetus’s growth and development. Drugs that are taken by pregnant woman take during pregnancy can affect the foetus in several ways

• They can act directly on the foetus, causing damage, abnormal development (leading to birth defects), or death.
• They can alter the function of the placenta, usually by causing blood vessels to narrow (constrict) and thus reducing the supply of oxygen and nutrients to the foetus from the mother. Sometimes the result is a baby that is underweight and underdeveloped.
• They can cause the muscles of the uterus to contract forcefully, indirectly injuring the foetus by reducing its blood supply or triggering preterm labour and delivery.

Only a thin membrane (placental membrane) separates the mother's blood in the intervillous space from the foetus’s blood in the villi. Drugs in the mother's blood can cross this membrane into blood vessels in the villi and pass through the umbilical cord to the foetus

How a drug affects a foetus depends on the foetus’s stage of development and the strength and dose of the drug. Certain drugs taken early in pregnancy (within 20 days after fertilization) may kill the foetus or not affecting it at all. During this early stage, the foetus is highly resistant to birth defects. However, the foetus is particularly vulnerable to birth defects between the 3rd and the 8th week after fertilization, when its organs are developing. Drugs reaching the foetus during this stage may have no effect, or they may cause a miscarriage, an obvious birth defect, or a permanent but subtle defect that is noticed later in life. Drugs taken after organ development is complete are unlikely to cause obvious birth defects, but they may alter the growth and function of normally formed organs and tissues.

The Food and Drug Administration (FDA) classifies drugs according to the degree of risk they pose for the foetus if they are used during pregnancy. Some drugs are highly toxic and should never be used by pregnant women because they cause severe birth defects. One example is thalidomide (Trade Name- THALOMID). Several decades ago, this drug caused extreme underdevelopment of arms and legs and defects of the intestine, heart, and blood vessels in the babies of women who took the drug during pregnancy. Some drugs cause birth defects in animals, but the same effects have not been seen in people. One example is meclizine (Trade name - ANTIVERT), frequently taken for motion sickness, nausea, and vomiting

Categories of Risk for Drugs during Pregnancy

Category	Description
A	These drugs are the safest. Well-designed studies in people show no risks to the foetus.
B	Studies in animals show no risk to the foetus, and no well-designed studies in people have been done. OR Studies in animals show a risk to the foetus, but well-designed studies in people do not.
C	No adequate studies in animals or people have been done. OR In animal studies, use of the drug resulted in harm to the foetus, but no information about how the drug affects the human fetus is available.
D	Evidence shows a risk to the human foetus, but benefits of the drug may outweigh risks in certain situations. For example, the mother may have a life-threatening disorder or a serious disorder that cannot be treated with safer drugs.
X	Risk to the foetus has been proved to outweigh any possible benefit.

Often,a safer drug can be substituted for one that is likely to cause harm during pregnancy. For an overactive thyroid gland, propylthiouracil is usually preferred. For prevention of blood clots, the anticoagulant heparin is preferred. Several safe antibiotics, such as penicillin, are available.

Some drugs can have effects after they are stopped. For example, isotretinoin (Trade Name- ACCUTANE), a drug used to treat skin disorders, is stored in fat beneath the skin and is released slowly. Isotretinoin (Trade name- ACCUTANE), can cause birth defects if women become pregnant within 2 weeks after the drug is stopped. Therefore, women are advised to wait at least 3 to 4 weeks after the drug is stopped before they become pregnant.

Vaccines made with a live virus (such as the rubella and varicella vaccines) are not given to women who are or might be pregnant. Other vaccines (such as those for cholera, hepatitis A and B, plague, rabies, tetanus, diphtheria, and typhoid) are given to pregnant women only if they are at substantial risk of developing that particular infection. However, all pregnant women who are in the 2nd or 3rd trimester during the influenza (flu) season should be vaccinated against the influenza virus.

Drugs to lower high blood pressure (antihypertensives) may be needed by pregnant women who have had high blood pressure before pregnancy or who develop it during pregnancy. Either type of high blood pressure increases the risk of problems for the woman and the foetus. However, antihypertensive drugs can markedly reduce blood flow to the placenta if they lower blood pressure too rapidly in pregnant women. So pregnant women who have to take these drugs are closely monitored. Two types of antihypertensives—Angiotensin Converting Enzyme (ACE) inhibitors and Thiazide diuretics, are usually not given to pregnant women because these drugs can cause serious problems in the foetus.

Digoxin (Trade name- LANOXIN), used to treat heart failure and some abnormal heart rhythms, readily crosses the placenta. But it typically has little effect on the baby before or after birth.

Some Drugs that can cause problems during pregnancy

Type	Examples	Problem
Antianxiety drug	Diazepam (T. Name- DIASTATVALIUM)	When the drug is taken late in pregnancy, depression, irritability, shaking, and exaggerated reflexes in the newborn
Antibiotics	Chloramphenicol (CHLORAMPHENICOL)	Gray baby syndrome. In women or fetuses with glucose-6-phosphate dehydrogenase (G6PD) deficiency, the breakdown of red blood cells
	Fluoroquinolones, such as ciprofloxacin (CILOXANCIPRO), ofloxacin (FLOXINOCUFLOX), levofloxacin (LEVAQUINQUIXIN) and norfloxacin (NOROXIN)	Possibility of joint abnormalities (seen only in animals)
	Kanamycin	Damage to the foetus’s ear, resulting in deafness
	Nitrofurantoin (FURADANTINMACRODANTIN)	In women or foetuses with G6PD deficiency, the breakdown of red blood cells
	Streptomycin	Damage to the fetus's ear, resulting in deafness
	Sulfonamides, such as sulfasalazine (AZULFIDINE), and trimethoprim- sulfamethoxazole	When the drugs are given late in pregnancy, jaundice and possibly brain damage in the newborn
	Tetracycline (SUMYCIN)	Slowed bone growth, permanent yellowing of the teeth, and increased susceptibility to cavities in the baby Occasionally, liver failure in the pregnant woman
Anticoagulants	Heparin	When the drug is taken a long time, osteoporosis and a decrease in the number of platelets (which help blood clot) in the pregnant woman
	Warfarin (COUMADIN)	Birth defects; Bleeding problems in the foetus and the pregnant woman
Anticonvulsants	Carbamazepine (TEGRETOL)	Some risk of birth defects Bleeding problems in the newborn, which can be prevented if pregnant women take vitamin K by mouth every day for a month before delivery or if the newborn is given an injection of vitamin K soon after birth
	Phenobarbital (LUMINAL)	Same as those for carbamazepine
	Phenytoin (DILANTIN)	Same as those for carbamazepine
	Trimethadione (TRIDIONE)	Increased risk of miscarriage in the woman High (70%) risk of birth defects, including a cleft palate and defects of the heart, face, skull, hands, or abdominal organs
	Valproate (DEPACON)	Some (1%) risk of birth defects, including a cleft palate and defects of the heart, face, skull, spine, or limbs
Antihypertensives	Angiotensin-converting enzyme (ACE) inhibitors	When the drugs are taken late in pregnancy, kidney damage in the fetus, a reduction in the amount of fluid around the developing fetus (amniotic fluid), and defects of the face, limbs, and lungs
	Beta-blockers	When some beta-blockers are taken during pregnancy, a slowed heart rate and low blood sugar level in the fetus and possibly slowed growth
	Thiazide diuretics	A decrease in the levels of oxygen, sodium, and potassium and in the number of platelets in the fetus's blood; Slowed growth
Chemotherapy drugs	Actinomycin	Possibility of birth defects (seen only in animals)
	Busulfan (MYLERAN)	Birth defects such as underdevelopment of the lower jaw, cleft palate, abnormal development of the skull bones, spinal defects, ear defects, and clubfoot Slowed growth
	Chlorambucil (LEUKERAN)	Same as those for busulfun
	Cyclophosphamide (LYOPHILIZED CYTOXAN)	Same as those for busulfun
	Mercaptopurine (PURINETHOL)	Same as those for busulfun
	Methotrexate (TREXALL)	Same as those for busulfun
	Vinblastine	Possibility of birth defects (seen only in animals)
	Vincristine	Possibility of birth defects (seen only in animals)
Mood-stabilizing drug	Lithium (LITHOBID)	Birth defects (mainly of the heart), lethargy, reduced muscle tone, poor feeding, underactivity of the thyroid gland, and nephrogenic diabetes insipidus in the newborn
Nonsteroidal anti-inflammatory drugs (NSAIDs)	Aspirin and other salicylates Ibuprofen (ADVILMOTRIN) Naproxen ( ALEVEANAPROXNAPROSYN)	When the drugs are taken in large doses, a delay in the start of labor, premature closing of the connection between the aorta and artery to the lungs (ductus arteriosus), jaundice, and (occasionally) brain damage in the fetus and bleeding problems in the woman during and after delivery and in the newborn When the drugs are taken late in pregnancy, a reduction in the amount of fluid around the developing fetus
Oral antihyperglycemic drugs	Chlorpropamide (DIABINESE)	A very low level of sugar in the blood of the newborn Inadequate control of diabetes in the pregnant woman When the drug is taken early in pregnancy by a woman with type 2 diabetes, possibility of increased risk of birth defects
	Tolbutamide	Same as those for chlorpropamide
Sex hormones	Danazol	When this drug is taken very early in pregnancy, masculinization of a female foetus’s genitals, sometimes requiring surgery to correct
	Diethylstilbestrol (DES)	Abnormalities of the uterus, menstrual problems, and an increased risk of vaginal cancer and complications during pregnancy in daughters Abnormalities of the penis in sons
	Synthetic progestins (but not the low doses used in oral contraceptives)	Same as those for danazol
Skin treatments	Etretinate	Birth defects, such as heart defects, small ears, and hydrocephalus (sometimes called water on the brain)
	Isotretinoin (ACCUTANE)	Same as those for etretinate Mental retardation Risk of miscarriage
Thyroid drugs	Methimazole (TAPAZOLE)	An enlarged or underactive thyroid gland in the fetus Scalp defects in the newborn
	Propylthiouracil	An enlarged or underactive thyroid gland in the fetus
	Radioactive iodine	Destruction of the thyroid gland in the fetus When the drug is given near the end of the 1st trimester, very overactive and enlarged thyroid gland in the fetus
	Triiodothyronine (THYROLAR)	An overactive and enlarged thyroid gland in the fetus
Vaccines (live virus)	Vaccine for German measles (rubella) and chickenpox (varicella)	Potential infection of the placenta and developing fetus
	Vaccines for measles, mumps, polio, or yellow fever	Potential but unknown risks
* Unless absolutely necessary, drugs should not be used during pregnancy. However, drugs are sometimes essential for the health of the pregnant woman and the foetus. In such cases, a woman should talk with her health care practitioner about the risks and benefits of taking the drugs.

Social Drugs

Cigarette (Tobacco) Smoking

Although cigarette smoking harms both pregnant women and the foetus, only about 20% of women who smoke quit during pregnancy. The most consistent effect of smoking on the foetus during pregnancy is a reduction in birth weight: The more a woman smokes during pregnancy, the less the baby is likely to weigh. The average birth weight of babies born to women who smoke during pregnancy is 170grms less than that of babies born to women who do not smoke. The reduction in birth weight seems to be greater among the babies of older smokers.

Birth defects of the heart, brain, and face are more common among babies of smokers than among those of nonsmokers. Also, the risk of sudden infant death syndrome (SIDS) may be increased. A dislocated placenta (placenta previa), premature detachment of the placenta, premature rupture of the membranes (containing the foetus), preterm labour, uterine infections, miscarriages, stillbirths, and premature births are also more likely. In addition, children of women who smoke have slight but measurable deficiencies in physical growth and in intellectual and behavioural development. These effects are thought to be caused by carbon monoxide and nicotine. Pregnant women should avoid exposure to second-hand smoke because it may similarly harm the foetus.

Alcohol

Drinking alcohol during pregnancy is the leading known cause of birth defects. Because the amount of alcohol required to cause foetal alcohol syndrome is unknown, pregnant women are advised to abstain from drinking any alcohol regularly or on binges; avoiding alcohol altogether may be even safer. The range of effects of drinking during pregnancy is great.

The risk of miscarriage almost doubles for women who drink alcohol in any form during pregnancy, especially if they drink heavily. Often, the birth weight of babies born to women who drink regularly during pregnancy is substantially below normal. The average birth weight is about 4 pounds for babies exposed to large amounts of alcohol, compared with 7 pounds for all babies. Newborns of women who drank during pregnancy may not thrive and are more likely to die soon after birth.

Foetal alcohol syndrome is one of the most serious consequences of drinking during pregnancy. Binge drinking as few as three drinks a day can cause this syndrome. It occurs in about 2 of 1,000 live births. This syndrome includes inadequate growth before or after birth, facial defects, a small head (probably caused by inadequate growth of the brain), mental retardation, and abnormal behavioral development. Less commonly, the position and function of the joints are abnormal and heart defects are present.

Babies or developing children of women who drank alcohol during pregnancy may have severe behavioural problems, such as antisocial behaviour and attention deficit disorder. These problems can occur even when the baby has no obvious physical birth defects.

Caffeine

Whether consuming caffeine during pregnancy harms the foetus is unclear. Evidence seems to suggest that consuming caffeine in small amounts (for example, one cup of coffee a day) during pregnancy poses little or no risk to the foetus. Caffeine, which is contained in coffee, tea, some sodas, chocolate, and some drugs, is a stimulant that readily crosses the placenta to the foetus. Thus, it may stimulate the foetus, increasing the heart rate. Caffeine also may decrease blood flow across the placenta and decreases the absorption of iron (possibly increasing the risk of anaemia). Some evidence suggests that drinking more than seven cups of coffee a day may increase the risk of having a stillbirth, premature birth, low-birth-weight baby, or miscarriage. Some experts recommend limiting coffee consumption and drinking decaffeinated beverages when possible.

Aspartame

Aspartame, an artificial sweetener, appears to be safe during pregnancy when it is consumed in small amounts, such as in amounts used in normal portions of artificially sweetened foods and beverages. Pregnant women with phenylketonuria, an unusual disorder, should not consume any aspartame.

Taking drugs while breastfeeding

When mothers who are breastfeeding have to take a drug, they should stop breastfeeding or not depends upon the following.

• How much of the drug passes into the milk
• Whether the drug is absorbed by the baby
• How the drug affects the baby
• How much milk the baby consumes, which depends on the baby's age and the amount of other foods and liquids in the baby's diet

Some drugs, such as epinephrine, heparin, and insulin (HUMULINNOVOLIN) do not pass into breast milk and are thus safe to take. Most drugs pass into breast milk but usually in tiny amounts. However, even in tiny amounts, some drugs can harm the baby. Some drugs pass into breast milk, but the baby usually absorbs so little of them that they do not affect the baby. Examples are the antibiotics gentamicin, kanamycin, streptomycin, and tetracycline.

Drugs that are considered safe include most non-prescription (over-the-counter) drugs. Exceptions are antihistamines (commonly contained in cough and cold remedies, allergy drugs, motion sickness drugs, and sleep aids) and, if taken in large amounts for a long time, aspirin and other salicylates.

Drugs that are applied to the skin, eyes, or nose or that are inhaled are usually safe. Most antihypertensive drugs do not cause significant problems in breastfed babies. Women may take beta-blockers during breastfeeding, but the baby should be checked regularly for possible side effects, such as a slow heart rate and low blood pressure. (COUMADIN) can be taken if the baby is full-term and healthy, but its use should be monitored. Caffeine and theophylline (THEOLAIR) do not harm breastfed babies but may make them irritable. The baby's heart and breathing rates may increase. Even though some drugs are reportedly safe for breastfed babies, women who are breastfeeding should consult a health care practitioner before taking any drug, even an over-the-counter drug, or a medicinal herb. All drug labels should be checked to see whether they contain warnings against use during breastfeeding.

Some drugs require a doctor's supervision during their use. Taking them safely while breastfeeding may require adjusting the dose, limiting the length of time the drug is used, or timing when the drug is taken in relation to breastfeeding. Most anti-anxiety drugs, antidepressants, and antipsychotic drugs require a doctor's supervision, even though they are unlikely to cause significant problems in the baby. However, these drugs stay in the body a long time. During the first few months of life, babies may have difficulty eliminating the drugs, and the drugs may affect the baby's nervous system. For example, the anti-anxiety drug diazepam (DIASTATVALIUM), a benzodiazepine, causes lethargy, drowsiness, and weight loss in breastfed babies. Babies eliminate phenobarbital (LUMINAL), an anticonvulsant and a barbiturate, slowly, so this drug may cause excessive drowsiness. Because of these effects, doctors reduce the dose of benzodiazepines and barbiturates as well as monitor their use by women who are breastfeeding.

Important precautions

• If women who are breastfeeding must take a drug that may harm the baby, they must stop breastfeeding. But they can resume breastfeeding after they stop taking the drug. While taking the drug, women can maintain their milk supply by pumping breast milk, which is then discarded.
• Women who smoke should not breastfeed within 2 hours of smoking and should never smoke in the presence of their baby whether they are breastfeeding or not. Smoking reduces milk production and interferes with normal weight gain in the baby.
• Alcohol consumed in large amounts can make the baby drowsy and cause profuse sweating.

Illicit Drugs

Use of illicit drugs (particularly opioids) during pregnancy can cause complications during pregnancy and serious problems in the developing foetus and the newborn. For pregnant women, injecting illicit drugs increases the risk of infections that can affect or be transmitted to the foetus. These infections include hepatitis and sexually transmitted diseases (including AIDS). Also, when pregnant women take illicit drugs, growth of the foetus is more likely to be inadequate, and premature births are more common.
Babies born to mothers who use cocaine often have problems, but whether cocaine is the cause of those problems is unclear. For example, the cause may be cigarette smoking, use of other illicit drugs, deficient prenatal care, or poverty.

Opioids

Opioids, such as heroin, methadone and morphine readily cross the placenta. Consequently, the foetus may become addicted to them and may have withdrawal symptoms 6 hours to 8 days after birth. However, use of opioids rarely results in birth defects. Use of opioids during pregnancy increases the risk of complications during pregnancy, such as miscarriage, abnormal presentation of the baby, and preterm delivery. Babies of heroin users are more likely to be small

Amphetamines

Use of amphetamines during pregnancy may result in birth defects, especially of the heart.

Marijuana

Whether use of marijuana during pregnancy can harm the foetus is unclear. The main component of marijuana, tetrahydrocannabinol, can cross the placenta and thus may affect the foetus. However, marijuana does not appear to increase the risk of birth defects or to slow the growth of the foetus. Marijuana does not cause behavioural problems in the newborn unless it is used heavily during pregnancy.

Drugs used during labour and delivery

Local anesthetics, opioids, and other analgesics usually cross the placenta and can affect the newborn. For example, they can weaken the newborn's urge to breathe. Therefore, if these drugs are needed during labour, they are given in the smallest effective doses. The baby's length may not increase normally, and the baby may gain excess weight.